英国皇家化学会主编推荐：纳米领域精彩文章快览

英国皇家化学会（RSC）是一个拥有超过175年历史的面向全球化学家的非营利会员制机构，旗下拥有44种期刊，其中很多在化学领域有很高影响力。 

Chemical Science (IF: 9.063)

1. A redox-activated theranostic nanoagent: toward multi-mode imaging guided chemo-photothermal therapy

Chem. Sci., 2018, Advance Article

DOI: 10.1039/C8SC02446D

Chinese researchers have developed a redox-sensitive nanoagent combining manganese dioxide (MnO₂) and gold nanoshell coated silicon nanoparticles for chemo-photothermal therapy of hypoxia solid tumors. The outer MnO₂ nanosheet with the loaded drug dissociates in highly reducing tumor tissues, resulting in targeted drug release and generating  Mn²⁺ ions for high contrast magnetic resonance imaging. Upon near-infrared light irradiation, the gold nanoshell modulates the hypoxic tumor microenvironment by increasing blood flow, giving enhanced photothermal therapy and chemotherapy.

南京大学的研究人员开发了一种对氧化还原敏感的纳米试剂，结合了二氧化锰（MnO₂）和金纳米壳包覆的硅纳米粒子，可以用于缺氧性实体瘤的化疗-光热疗法。负载了药物的外部MnO₂纳米层在高还原性的肿瘤组织中解离，实现靶向药物释放的同时产生Mn²⁺离子，可用于高对比度磁共振成像。在近红外光照射下，金纳米壳通过增加血流来调节缺氧性肿瘤内的微环境，增强光热疗法和化疗的效果。

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2. Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants

Chem. Sci., 2018, Advance Article

DOI: 10.1039/C8SC02761G

Scientists in China and Canada have reported a nicking endonuclease-powered 3D DNA nanomachine for identifying single nucleotide varients (SNVs) with high sensitivity and specificity. The requirement of high energy input for most existing 3D DNA walking devices means they are generally not viable for discriminating SNVs. The simulation-guided strategy used here optimises the sequence design of the nanomachine to find a balance of efficiency and specificity, improving the assay sensitivity by ~100 times.

四川大学与加拿大布鲁克大学的研究人员合作报道了一种切刻内切酶驱动的三维DNA纳米机器，可以高灵敏、高特异性地鉴别单核苷酸变异（SNVs）。大多数现有的三维DNA行走器件都需要高能量输入，这意味着它们通常不能用于区分单核苷酸变异。本文使用的模拟引导策略优化了纳米机器的序列设计，可以平衡效率与特异性，将灵敏度提高了约100倍。

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Nanoscale Horizons (IF: 9.391)

1. Highly monodisperse beta-cyclodextrin-covellite nanoparticles for efficient photothermal and chemotherapy

Nanoscale Horiz., 2018, Advance Article

DOI: 10.1039/C8NH00026C

The potency of copper sulfide nanomaterials in the fields of cancer therapy, molecular imaging and even photocatalysis is limited due to their numerous stoichiometries, which greatly influence their localized surface plasmon resonance. Here, by choosing suitable copper and sulfide precursors, and carefully optimizing the reaction conditions, the authors were able to obtain high quality covellite phase copper sulfide nanoparticles using a facile non-hot injection method. Together with their outstanding photothermal conversion efficiency, they can serve as efficient photoacoustic and photothermal agents.

因为硫化铜纳米材料具有的多种化学计量比极大地影响了其局域表面等离激元共振，使其在癌症治疗、分子成像甚至光催化领域的发展潜力受到了限制。本文中，通过选择合适的铜和硫化物前体，并仔细优化反应条件，作者们使用简便的非热注入法获得了高质量的铜蓝相硫化铜纳米颗粒。这种纳米材料具有出色的光热转换效率，可以作为高效的光声剂和光热剂。

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2. Review on nanoscale Bi-based photocatalysts

Nanoscale Horiz., 2018, Advance Article

DOI: 10.1039/C8NH00062J

Nanoscale Bi-based photocatalysts are promising candidates for visible-light-driven photocatalytic environmental remediation and energy conversion. Herein, recent topics including doping, changing stoichiometry, solid solutions, ultrathin nanosheets, hierarchical and hollow architectures, conventional heterojunctions, direct Z-scheme junctions, and surface modification of conductive materials and semiconductors, are reviewed. The progress in the enhancement mechanism involving light absorption, band structure tailoring, and separation and utilization of excited carriers, is also introduced. The challenges and tendencies in the studies of nanoscale Bi-based photocatalysts are discussed and summarized.

纳米级铋基光催化剂在可见光驱动的光催化环境修复和能量转换中具有很好的应用前景。本篇综述总结了与之相关的近期进展，包括掺杂、化学计量改变、固溶体、超薄纳米片、分级和中空结构、常规异质结、直接Z-型结以及导电材料和半导体的表面改性。此外，还介绍了涉及光吸收、带结构调整以及激发载流子的分离和利用的增强机制的进展，并讨论和总结了纳米级铋基光催化剂研究中的挑战和趋势。

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3. Activating basal plane in NiFe layered double hydroxide by Mn²⁺ doping for efficient and durable oxygen evolution reaction

Nanoscale Horiz., 2018, Advance Article

DOI: 10.1039/C8NH00121A

As benchmark electrocatalysts for oxygen evolution reaction (OER), NiFe layered double hydroxides (NiFe-LDHs) are known to comprise active edge sites, while the basal plane remains inert. Activating the basal plane could fully utilize the NiFe-LDHs materials, but it still remains a challenge. Herein, the authors report the activation of basal plane in NiFe-LDHs for OER by introducing foreign metal ions with weaker electronegativity to Ni and Fe. This study illustrates a new dimension of electronic structure regulation and promises further optimization of high efficiency electrocatalysts.

作为析氧反应（OER）中的基准电催化剂，镍铁层状双氢氧化物（NiFe LDHs）已被熟知含有活性边缘位点，而基面则保持惰性。激活基面虽可更充分地利用NiFe-LDHs材料，但如何实现仍然是一个挑战。本文作者报道了参与析氧反应的NiFe-LDH基面的激活方法，即引入了比Ni和Fe的电负性更弱的外来金属离子。该研究展示了调节电子结构的新维度，有助于高效电催化剂的进一步优化。

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