V4
小小的梦想 声望 83
生物科学
Am I ready for CRISPR? A user's guide to genetic screens
作者:John G. Doench
摘要:Exciting new technologies are often self-limiting in their rollout, as access to state-of-the-art instrumentation or the need for years of hands-on experience, for better or worse, ensures slow adoption by the community. CRISPR technology, however, presents the opposite dilemma, where the simplicity of the system enabled the parallel development of many applications, improvements and derivatives, and new users are now presented with an almost paralyzing abundance of choices. This Review intends to guide users through the process of applying CRISPR technology to their biological problems of interest, especially in the context of discovering gene function at scale.
关键词:CRISPR-Cas9 genome editingFunctional genomicsGenetic engineeringHigh-throughput screening
论文方向:
发表期刊:NATURE REVIEWS GENETICS
数字识别码:doi:10.1038/nrg.2017.97
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