The steroid receptor RNA activator protein (SRAP) controls cancer cell migration/motility
摘要：Abstract The steroid receptor RNA activator gene (SRA1) produces both a functional RNA (SRA) and a protein (SRAP), whose exact physiological roles remain unknown. To identify cellular processes regulated by SRAP we compared the transcriptome of Hela and MDA-MB-231 cancer cells upon depletion of the SRA/SRAP transcripts or overexpression of the SRAP protein. RNA-seq and Ontology analyses pinpointed cellular movement as potentially regulated by SRAP. Using live cell imaging, we found that SRA/SRAP depletion and SRAP overexpression lead respectively to a decrease and increase in cancer cell motility. Our results highlight for the first time a link existing between SRA1 gene expression and cell motility.
关键词：SRA steroid receptor RNA activator; steroid receptor RNA activator; SRAP steroid receptor RNA protein; steroid receptor RNA protein; RT-qPCR reverse transcription-real time quantitative PCR; reverse transcription-real time quantitative PCR; Steroid receptor RNA activator; Non-coding RNA; Functional RNA; Cell motility; Cancer; Steroid receptor RNA activator; Steroid receptor RNA protein
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 589, Issue 24, Part B
发表时间：Mon Dec 21 00:00:00 CST 2015
数字识别码：10.1016/j.febslet.2015.11.007
是否作者本人： 否
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