Differentiation of monocyte-derived dendritic cells is associated with upregulation and activation of Rac-1 small GTPase
摘要：Abstract Critical changes occurring in Rac-1 molecule, a cytoskeleton organizing small GTPase associated with cell ruffling, have been analyzed in dendritic cells (DCs) derived from monocytes cultured with granulocyte-macrophage colony-stimulating factor and IFN-α or IL-4. Although with different kinetics, both agents induced activation of Rac-1 molecule and, more importantly, an upregulation of both protein expression and mRNA transcription. These findings strengthen the role of Rac-1 molecule in the induction of DC differentiation and suggest that, besides its activation, the upregulation of Rac-1 molecule might also play a role in the acquisition of DC mature phenotype.
关键词：DCs dendritic cells; dendritic cells; GM-CSF granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; IFN-α interferon α; interferon α; IL-4 interleukin 4; interleukin 4; LPS lipopolysaccharide; lipopolysaccharide; SEM scanning electron microscopy; scanning electron microscopy; Dendritic cells; Rac-1; Interleukin-4; Interferon-α; Cytoskeleton; Small GTPases
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 580, Issue 13
发表时间：Mon May 29 00:00:00 CST 2006
数字识别码：10.1016/j.febslet.2006.04.095
是否作者本人： 否
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