Involvement of the brain type of ryanodine receptor in T-cell proliferation
摘要：Abstract Cloning and sequence analysis of cDNA showed that the brain type of ryanodine receptor (RYR) is expressed in human Jurkat T-lymphocyte cells. Fura-2 measurements revealed that the RYR in T-cells functions as a ryanodine-sensitive, caffeine-insensitive Ca2+ release channel. Furthermore, ryanodine stimulated proliferation and altered the growth pattern of cultured human T-cells when added together with FK506.
关键词：Ryanodine receptor; cDNA cloning; Calcium release; Cell proliferation; FK506; Jurkat T-lymphocyte; RYR, ryanodine receptor; CICR, calcium-induced calcium release; FKBP, FK506-binding protein; [Ca2+]i, intracellular calcium concentration.
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 352, Issue 2
发表时间：Mon Sep 26 00:00:00 CST 1994
数字识别码：10.1016/0014-5793(94)00955-4
是否作者本人： 否
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