Sphingosine 1-phosphate transactivates c-Met as well as epidermal growth factor receptor (EGFR) in human gastric cancer cells
摘要：Abstract Receptor tyrosine kinases (RTKs) are transactivated by the stimulation of G protein-coupled receptors (GPCRs). Sphingosine 1-phosphate (S1P), a ligand of GPCR, is known as a tumor-promoting lipid, but its signaling pathways are not fully understood. We here demonstrated that S1P induces rapid and transient tyrosine phosphorylation of epidermal growth factor receptor (EGFR) and c-Met in gastric cancer cells, both of which have been proposed as prognostic markers of gastric cancers. The pathway of S1P-induced c-Met transactivation is Gi-independent and matrix metalloproteinase-independent, which differs from that of EGFR transactivation. Our results indicate that S1P acts upstream of various RTKs and thus may act as a potent stimulator of gastric cancer.
关键词：EGF, epidermal growth factor; GPCR, G protein-coupled receptor; HB-EGF, heparin-binding EGF-like growth factor; HGF, hepatocyte growth factor; HUVEC, human umbilical vein endothelial cell; LPA lysophosphatidic acid; MMP, matrix metalloproteinase; PTX, pertussis toxin; RTK, receptor tyrosine kinase; S1P, sphingosine 1-phosphate; VEGF, vascular endothelial growth factor; VSMC, vascular smooth muscle cell; Sphingosine 1-phosphate; Transactivation; Receptor tyrosine kinase; c-Met; Epidermal growth factor receptor; Gastric cancer cell
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 577, Issue 3
发表时间：Fri Nov 19 00:00:00 CST 2004
数字识别码：10.1016/j.febslet.2004.10.024
是否作者本人： 否
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