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Regulatory sequences required for hst-1 expression in embryonal carcinoma cells
作者:, Mitsuaki Kakinuma
摘要:Abstract The hst-1 gene, which is implicated in mammalian embryonic development and morphological transformation of NIH3T3 cells, is expressed in undifferentiated F9 cells, but not in differentiated F9 and other well-differentiated cells, such as PYS-2, NIH3T3 and HeLa cells. An octamer element present in the 3' untranslated region acts as an enhancer. Although Oct3 is down-regulated when F9 cells are differentiated, transient expression of Oct3 did not enhance the hst-1 promoter activity in HeLa, NIH3T3 or PYS-2 cells. Thus, the role of Oct3 on hst-1 expression remains elusive, and an additional transcription factor which interacts may regulate hst-1 transcription in association with Oct1, Oct3 or both.
关键词:hst-1/K-FGF/FGF4; oct-3; Enhancer; F9; Differentiation
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发表期刊:FEBS Letters Volume 342, Issue 1
发表时间:Mon Mar 28 00:00:00 CST 1994
数字识别码:10.1016/0014-5793(94)80587-3
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