Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations
摘要：Abstract We studied the effects of cytostatic drugs on porcine coronary artery spindle-shaped (S) and rhomboid (R) smooth muscle cell (SMC) biological activities related to intimal thickening (IT) formation. Imatinib, and to a lesser extent curcumin, decreased proliferation of S- and R-SMCs and migratory and urokinase activities of R-SMCs more efficiently compared with cyclosporine plus rapamycin. Imatinib increased the expression of α-smooth muscle actin in both SMC populations and that of smoothelin in S-SMCs. It decreased S100A4 expression in R-SMCs. By promoting SMC quiescence and differentiation imatinib and curcumin may represent valid candidates for restenosis preventive and therapeutic strategies.
关键词：Imatinib; Curcumin; Cyclosporine; Rapamycin; Smoothelin; S100A4
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 581, Issue 30
发表时间：Sat Dec 22 00:00:00 CST 2007
数字识别码：10.1016/j.febslet.2007.11.060
是否作者本人： 否
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