The differentiation antigen Ly-6E.1 is expressed in mouse metastatic tumor cell lines
摘要：Abstract We report the cloning of the mouse surface GPI-anchored Ly-6E.1 protein from a highly metastatic mouse adenocarcinoma cell line CSML-100 by differential display. The expression is specific for the metastatic cell line as the closely related, non-metastatic mouse adenocarcinoma cell line CSML-0 does not express Ly-6E.1. Northern blot analysis reveals expression in a number of mouse tumour cell lines, exclusively metastatic ones. To date, active Ly-6A/E has only been described in lymphoid cells. The correlation between Ly-6E.1 expression, and the ability to metastasize, is discussed. © Federation of European Biochemical Societies.
关键词：Tumor progression; Ly-6E.1; Metastasis; Adhesion; Differential display; GPI glycosyl phoshatidyl inositol; glycosyl phoshatidyl inositol; RT-PCR reverse transcription-polymerase chain reaction; reverse transcription-polymerase chain reaction; SDS sodium dodecyl sulphate; sodium dodecyl sulphate; PAGE polyacrylamide gel electrophoresis; polyacrylamide gel electrophoresis; bp base pair(s); base pair(s); PMSF phenylmethylsulfonyl fluoride; phenylmethylsulfonyl fluoride; DTT dl-dithiothreitol; dl-dithiothreitol; mAb monoclonal antibody; monoclonal antibody; pAb polyclonal antibody; polyclonal antibody
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 403, Issue 2
发表时间：Mon Feb 17 00:00:00 CST 1997
数字识别码：10.1016/S0014-5793(97)00050-1
是否作者本人： 否
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