Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling
作者:, Siro Simizu
摘要:Abstract Epithelial to mesenchymal transition (EMT) is an important mechanism for the initial step of metastasis. Proteomic analysis indicates that Pirin is involved in metastasis. However, there are no reports demonstrating its direct contribution. Here we investigated the involvement of Pirin in EMT. In HeLa cells, Pirin suppressed E-cadherin expression and regulated the expression of other EMT markers. Furthermore, cells expressing Pirin exhibited a spindle-like morphology, which is reminiscent of EMT. A Pirin mutant defective for Bcl3 binding decreased E-cadherin expression similar to wild-type, suggesting that Pirin regulates E-cadherin independently of Bcl3-Slug signaling. These data provide direct evidence that Pirin contributes to cancer metastasis.
关键词:E-cadherin; Epithelial to mesenchymal transition; Metastasis; Morphological change; Pirin
论文方向:[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊:FEBS Letters Volume 589, Issue 6
发表时间:Thu Mar 12 00:00:00 CST 2015
数字识别码:10.1016/j.febslet.2015.01.040
是否作者本人: 否
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