Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson’s disease
作者:, Eunsung Junn
摘要:Abstract Mounting evidence suggests that microRNA (miR) dysregulation contributes to neurodegenerative disorders including Parkinson’s disease (PD). MiR-34b and miR-34c have been previously shown to be down-regulated in the brains of patients with PD. Here, we demonstrate that miR-34b and miR-34c repress the expression of α-synuclein (α-syn), a key protein in PD pathogenesis. Inhibition of miR-34b and miR-34c expression in human dopaminergic SH-SY5Y cells increased α-syn levels and stimulated aggregate formation. Additionally, a single nucleotide polymorphism (SNP) in the 3′-UTR of α-syn was found to lower the miR-34b-mediated repression of the protein. Our results suggest that down-regulation of miR-34b and miR-34c in the brain, as well as an SNP in the 3′-UTR of α-syn can increase α-syn expression, possibly contributing to PD pathogenesis.
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论文方向:[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊:FEBS Letters Volume 589, Issue 3
发表时间:Fri Jan 30 00:00:00 CST 2015
数字识别码:10.1016/j.febslet.2014.12.014
是否作者本人: 否
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