Rheumatoid arthritis
作者:, Iain B McInnes
摘要:Summary Rheumatoid arthritis is a chronic inflammatory joint disease, which can cause cartilage and bone damage as well as disability. Early diagnosis is key to optimal therapeutic success, particularly in patients with well-characterised risk factors for poor outcomes such as high disease activity, presence of autoantibodies, and early joint damage. Treatment algorithms involve measuring disease activity with composite indices, applying a treatment-to-target strategy, and use of conventional, biological, and newz non-biological disease-modifying antirheumatic drugs. After the treatment target of stringent remission (or at least low disease activity) is maintained, dose reduction should be attempted. Although the prospects for most patients are now favourable, many still do not respond to current therapies. Accordingly, new therapies are urgently required. In this Seminar, we describe current insights into genetics and aetiology, pathophysiology, epidemiology, assessment, therapeutic agents, and treatment strategies together with unmet needs of patients with rheumatoid arthritis.
关键词:
论文方向:[{"id":13,"name":"细胞生物学"},{"id":896,"name":"医药科学"}]
发表期刊:The Lancet Volume 388, Issue 10055
发表时间:Fri Oct 28 00:00:00 CST 2016
数字识别码:10.1016/S0140-6736(16)30173-8
是否作者本人: 否
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