Threshold of Microvascular Occlusion: Injury Size Defines the Thrombosis Scenario
作者:, Fazly I. Ataullakhanov
摘要:Abstract Damage to the blood vessel triggers formation of a hemostatic plug, which is meant to prevent bleeding, yet the same phenomenon may result in a total blockade of a blood vessel by a thrombus, causing severe medical conditions. Here, we show that the physical interplay between platelet adhesion and hemodynamics in a microchannel manifests in a critical threshold behavior of a growing thrombus. Depending on the size of injury, two distinct dynamic pathways of thrombosis were found: the formation of a nonocclusive plug, if injury length does not exceed the critical value, and the total occlusion of the vessel by the thrombus otherwise. We develop a mathematical model that demonstrates that switching between these regimes occurs as a result of a saddle-node bifurcation. Our study reveals the mechanism of self-regulation of thrombosis in blood microvessels and explains experimentally observed distinctions between thrombi of different physical etiology. This also can be useful for the design of platelet-aggregation-inspired engineering solutions.
关键词:
论文方向:[{"id":13,"name":"细胞生物学"},{"id":19,"name":"生物物理学"}]
发表期刊:Biophysical Journal Volume 109, Issue 2
发表时间:Tue Jul 21 00:00:00 CST 2015
数字识别码:10.1016/j.bpj.2015.06.019
是否作者本人: 否
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