2个回答
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1、Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through a phosphatase activity- and PI-3K-independent mechanism. 3、Expression and localization of TLR4 and its negative regulator Tollip in the placenta of early-onset and late-onset preeclampsia。 4、氧化苦参碱(OMT)对糖尿病大鼠视网膜TOLL受体4和核因子-κB表达水平的影响。氧化苦参碱可抑制NF—kB,降低多种炎症因子的活化,具有抗凋亡的药理作用，应用抗炎药OMT能够通过有效抑制TLR4和NF-kB的表达,减轻视网膜各层紊乱程度,减少神经节细胞数目丢失,降低糖尿病大鼠视网膜损伤。 |