Grim-19是细胞死亡调节蛋白，对于线粒体复合体I的装配和功能是必需的。对死亡细胞染色观察，对比Grim-19的甲基化与细胞死亡的关联。可以把Grim-19蛋白分离出来，研究与其他蛋白的互作。

NDUFA13 has a homologous protein known as GRIM-19, a cell-death regulatory protein. It is involved in interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This form of apoptotic activity is inhibited by interaction with viral IRF1. GRIM-19 prevents the transactivation of signal-transducer and activator of transcription 3 (STAT3) target genes but not other STAT family members.