MicroRNA-29a regulates pro-inflammatory cytokine secretion and scavenger receptor expression by targeting LPL in oxLDL-stimulated dendritic cells
摘要：Abstract There is increasing evidence that microRNAs (miRNAs) play important roles in cell proliferation, apoptosis and differentiation that accompany inflammatory responses. However, whether microRNAs are associated with DC immuno-inflammatory responses with oxidized low density lipoprotein (oxLDL) stimulation is not yet known. Our study aims to explore the link of miRNAs with lipid-overload and immuno-inflammatory mechanism for atherosclerosis. In DCs transfected with microRNA-29a mimics or inhibitors, we showed that microRNA-29a plays an important role in proinflammatory cytokine secretion and scavenger receptor expression upon oxLDL-treatment. Furthermore, we suggest an additional explanation for the mechanism of microRNA-29a regulation of its functional target, lipoprotein lipase. We conclude that microRNA-29a could regulate pro-inflammatory cytokine secretion and scavenger receptor expression by targeting lipoprotein lipase in oxLDL-stimulated dendritic cells.
关键词：DC dendritc cell; dendritc cell; miRNA microRNA; microRNA; OxLDL oxidized low density lipoprotein; oxidized low density lipoprotein; TNF-α tumor necrosis factor-α; tumor necrosis factor-α; IL interleukin; interleukin; LPL lipoprotein lipase; lipoprotein lipase; LOX-1 lectin-like oxidized low-density lipoprotein receptor-1; lectin-like oxidized low-density lipoprotein receptor-1; UTR untranslated regions; untranslated regions; SRA scavenger receptor A; scavenger receptor A; MicroRNA-29a; Oxidized low density lipoprotein; Dendritic cell; Lipoprotein lipase; Immuno-inflammation
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 585, Issue 4
发表时间：Fri Feb 18 00:00:00 CST 2011
数字识别码：10.1016/j.febslet.2011.01.027
是否作者本人： 否
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