Involvement of integrins and the cytoskeleton in modulation of skeletal muscle glycogen synthesis by changes in cell volume
摘要：Abstract Muscle glycogen synthesis is modulated by physiologically relevant changes in cell volume. We have investigated the possible involvement of integrin-extracellular matrix interactions in this process using primary cultures of rat skeletal muscle subject to hypo- or hyper-osmotic exposure with integrin binding peptide GRGDTP to disrupt integrin actions and the inactive analogue GRGESP as control. Osmotically induced increases (77%) and decreases (34%) in glycogen synthesis (d-[14C]-glucose incorporation into glycogen) were prevented by GRGDTP (but not GRGESP) without affecting glucose transport. Cytoskeletal disruption with cytochalasin D or colchicine had similar effects to GRGDTP. Osmotically induced modulation of muscle glycogen synthesis involves integrin-extracellular matrix interactions and cytoskeletal elements, possibly as components of a cell-volume `sensing' mechanism.
关键词：Integrin; Glycogen synthesis; Cell volume; Skeletal muscle; Cytoskeleton; MAP kinase mitogen-activated protein kinase; mitogen-activated protein kinase; PI3-kinase phosphatidylinositol 3-kinase; phosphatidylinositol 3-kinase; FAK focal adhesion kinase; focal adhesion kinase
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 417, Issue 1
发表时间：Mon Nov 03 00:00:00 CST 1997
数字识别码：10.1016/S0014-5793(97)01264-7
是否作者本人： 否
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