An arachidonic acid generation/export system involved in the regulation of cholesterol transport in mitochondria of steroidogenic cells
摘要：Abstract Recent studies demonstrated the importance of the mitochondrial ATP in the regulation of a novel long-chain fatty acid generation/export system in mitochondria of diabetic rat heart. In steroidogenic systems, mitochondrial ATP and intramitochondrial arachidonic acid (AA) generation are important for steroidogenesis. Here, we report that mitochondrial ATP is necessary for the generation and export of AA, steroid production and steroidogenic acute regulatory protein induction supported by cyclic 3′–5′-adenosine monophosphate in steroidogenic cells. These results demonstrate that ATP depletion affects AA export and provide new evidence of the existence of the fatty acid generation and export system involved in mitochondrial cholesterol transport.
关键词：AA arachidonic acid; arachidonic acid; StAR protein steroidogenic acute regulatory protein; steroidogenic acute regulatory protein; cAMP cyclic 3′–5′-adenosine monophosphate; cyclic 3′–5′-adenosine monophosphate; P450scc side chain cleavage cytochrome P450; side chain cleavage cytochrome P450; PBR peripheral benzodiazepine receptor; peripheral benzodiazepine receptor; Acot2 mitochondrial acyl-CoA thioesterase; mitochondrial acyl-CoA thioesterase; ACS4 acyl-CoA synthetase 4; acyl-CoA synthetase 4; CCCP carbonyl cyanide m-chlorophenyl hydrazone; carbonyl cyanide m-chlorophenyl hydrazone; Arachidonic acid; Steroidogenesis; Mitochondria; Cholesterol transport
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 581, Issue 21
发表时间：Tue Aug 21 00:00:00 CST 2007
数字识别码：10.1016/j.febslet.2007.07.040
是否作者本人： 否
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