Expression of the T4 molecule (AIDS virus receptor) by human brain-derived cells
摘要：Abstract Three human cell lines of astrocytic origin were evaluated for expression of a human T-lymphocyte surface glycoprotein, T4, which also serves as a cellular receptor for the human immunodeficiency virus (AIDS virus, HIV). T4 antigen was detected on the cell surface of 2 of these cell lines using monoclonal OKT-4 antibody and flow cytometry. Gene transcripts encoding the T4 molecule were detected by a ribonuclease protection assay in surface T4-positive and -negative cells. Our results suggest that astrocytes may serve as targets for HIV infection in the brain.
关键词：Human immunodeficiency virus (HIV); AIDS; HIV receptor; Astrocyte; T4 antigen; Glial fibrillary acidic protein; HIV, human immunodeficiency virus; AIDS, acquired immune deficiency syndrome; GFAP, glial fibrillary acidic protein
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 213, Issue 1
发表时间：Mon Mar 09 00:00:00 CST 1987
数字识别码：10.1016/0014-5793(87)81478-3
是否作者本人： 否
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