Potential anti-atherogenic cell action of the naturally occurring 4-O-methyl derivative of gallic acid on Ang II-treated macrophages
摘要：Abstract We have recently established that the blood concentrations of gallic acid (GA), a polyphenolic component naturally found in food, and its O-methyl derivatives are very low (practically ⩽1 μM) in physiological (postprandial) condition. Using acellular oxidant systems and macrophage-differentiated promonocytes (MDPs) THP-1, we show here that the direct and indirect (through depressing effect on the superoxide cell production) antioxidant properties of these components were not effective at these concentrations. In contrast, 4-O-methyl GA was the most efficient component to depress AT1R and CD36 mRNA expression in Ang II-treated MDPs, suggesting a strong inhibition of Ang II-triggered pro-atherogenic mechanisms of foam cell formation.
关键词：Low-density lipoprotein; Superoxide; Macrophage-differentiated THP-1; Ang II type 1 receptor; CD36; AAPH, 2-2′-azobis-(2-amidinopropane)-hydrochloride; Ang II, angiotensin II; AT1R, Ang II type 1 receptor; CD, conjugated dienes; GA, gallic acid; 3-OMGA and 4-OMGA, 3-O-methyl gallic acid and 4-O-methyl gallic acid; MDP, macrophage-differentiated promonocyte; PMA, phorbol-12-myristate-13-acetate; PP, polyphenols; RDI, retinoic acid, vitamin D3, interferon γ; SIN-1, 3-morpholinosydnonimine
论文方向：[{"id":13,"name":"细胞生物学"},{"id":879,"name":"生物化学"}]
发表期刊：FEBS Letters Volume 577, Issues 1–2
发表时间：Fri Nov 05 00:00:00 CST 2004
数字识别码：10.1016/j.febslet.2004.10.015
是否作者本人： 否
版权及免责声明：
本网站所有论文文件均系用户自行上传或提供，本网站对其内容准确性及合法性概不负责，亦不承担任何法律责任。论文版权归原作者及原出处所有。
如您发现网站其他用户上传的论文有侵犯您的姓名权、隐私权、著作权或其他合法权益现象的，请及时与本网站联系并附加相关权利证明文件，以便本网站及时作出处理，维护您的合法权益。
本网站拥有对此声明的最终解释权。
{replyUser1} 回复 {replyUser2}：{content}